Recombinant Fsh: (Puregon Preclinical and Clinical Experiences) (Studies in Profertility Series, V. 5) by H. J. Out (Editor), Herman Jan Tymen Coelingh Bennink (Editor) Purchase at:  Amazon.com  Format: Hardcover, 1st ed., 178pp.  ISBN: 1850707464 Publisher: Prthnon Pu  Pub. Date: August 1996

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Researchers and clinicians relate their experiences in northern European hospitals and clinics with a new preparation the Dutch company Organon has developed to use in gonadotrophic therapy to induce ovulation. Drawing from recombinant DNA sources, Puregon is hoped to produce greater purity and batch-to-batch consistency. Five of the 13 articles, reprinted from professional journals discuss preclinical aspects, while the rest focus on clinical aspects. Annotation c. by Book News, Inc., Portland, Or.

Table of Contents

List of principal contributors

Preface

Acknowledgements 1 Comparative in vitro and in vivo studies on the biological characteristics of recombinant human follicle-stimulating hormone    3

2 Effects of recombinant human follicle stimulating hormone on cultured human granulosa cells: comparison with urinary gonadotrophins and actions in preovulatory follicles    23

3 Circulating bioactive and immunoreactive recombinant human follicle stimulating hormone (Org 32489) after administration to gonadotropin-deficient subjects   35

4 Folliculogenesis in hypophysectomized rats after treatment with recombinant human follicle-stimulating hormone   49

5 First established pregnancy and birth after ovarian stimulation with recombinant human follicle stimulating hormone (Org 32489)    69

6 Human recombinant follicle-stimulating hormone induces growth of preovulatory follicles without concomitant increase in androgen and estrogen biosynthesis in a woman with isolated gonadotropin deficiency   75

7 Single-dose pharmacokinetics and pharmocodynamics of recombinant human follicle-stimulating hormone (Org 32489) in gonadotropin-deficient volunteers

8 Clinical outcome of a pilot efficacy study on recombinant human follicle-stimulating hormone (Org 32489) combined with various gonadotrophin-releasing hormone agonist regimens   99

9 Recombinant human follicle-stimulating hormone and ovarian response in gonadotrophin-deficient women   115

10 First established pregnancy and birth after induction of ovulation with recombinant human follicle-stimulating hormone in polycystic ovary syndrome   131

11 Recombinant human follicle-stimulating hormone and human chorionic gonadotropin for induction of spermatogenesis in a hypogonadotropic male   137

12 Efficacy and safety of recombinant follicle stimulating hormone (Puregon) in infertile women pituitary-suppressed with triptorelin undergoing in-vitro fertilization: a prospective, randomized, assessor-blind, multicentre trial

13 A prospective, randomized, assessor-blind, multicentre study comparing recombinant and urinary follicle stimulating hormone (Puregon versus Metrodin) in in-vitro fertilization   157

Index   175